Virginia Mayo was born Virginia Jones in St. Louis, Missouri, in 1920.
Trained as a dancer, Mayo started her career in vaudeville. In 1939, at the age of 19, she made her film debut in a short-reel for Mentone.
Mayo made her Broadway debut in 1941 and appeared in her first full film feature in 1943. She appeared in more than 50 motion pictures through 1997.
Mayo turned to television guest roles in the mid 1950s and was a semi-regular in the prime time soap opera Santa Barbara (1984).
In 1947, she married actor Michael O'Shea, who died in 1973. They had one child.
Mayo died in Los Angeles, in 2005, at the age of 84.